The Lazzaretto of Ancona, also called the Mole Vanvitelliana, is an 18th-century building constructed on an artificial island for the purpose of serving as quarantine station and Leprosarium for the port town of Ancona.
The pentagonal building rises on an artificial island in the port which is now connected to the mainland by three bridges. It was a project commissioned by Pope Clement XII, designed by the architect Luigi Vanvitelli, and built (1733−1743). It has originally had no land link to the mainland.
Over the years, the site has taken different functions, mainly as a military citadel since the 19th century. During World War I, there was a failed attempt to sabotage the Italian naval resources by 60 infiltrating Habsburg sailors. Now it is used as a site of the museum Tattile Omero, as well as home for various exhibitions.